Variability in sensitivity to inflammation in muscle and lung of patients with COPD may underlie susceptibility to lung function decline
In patients at the severe end of the COPD spectrum, the proinflammatory response in muscle predominates, whereas in patients at the mild end of the spectrum, the anti-inflammatory response predominates. This suggestion needs confirming in a longitudinal cohort.
Authors
- Mark Griffiths (ORCID: https://orcid.org/0000-0002-1615-1896)
- Michael I. Polkey (ORCID: https://orcid.org/0000-0003-1243-8571)
- Paul R. Kemp (ORCID: https://orcid.org/0000-0001-8975-7293)
- S A Sathyapala (ORCID: https://orcid.org/0000-0001-7887-4494)
Institutions
- St Bartholomew's Hospital (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Lung Institute (US)
- St. Thomas Hospital (CA)
- Imperial College London (GB)
Publication Details
- Journal
- Thorax
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1136/thorax-2024-221901
- Citations
- 1
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Wellcome Trust