Neurosyphilis: An Uncommon Diagnosis in the Antibiotic Era

Neurosyphilis results from infection of the nervous system by <i>Treponema pallidum</i>. The diagnosis of neurosyphilis is overlooked because of its rarity. It can manifest as early or late symptoms after primary infection with syphilis, with symptoms lying on the spectrum of asymptomatic early neurosyphilis, syphilitic meningitis, meningovascular syphilis, general paresis, and tabes dorsalis. In this report, we present a case of neurosyphilis presenting with acute confusion and agitation.

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Publication Details

Journal
Cureus
Published
2025-04-16
DOI
https://doi.org/10.7759/cureus.82383
Primary Topic
Syphilis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Neurosyphilis: An Uncommon Diagnosis in the Antibiotic Era

Azeem Danish, Anwar Ali, Muhammad Umar Khan, Muhammad Ijaz Khan
Cureus
Syphilis Diagnosis and Treatment
article

Neurosyphilis: An Uncommon Diagnosis in the Antibiotic Era

Azeem Danish, Anwar Ali, Muhammad Umar Khan, Muhammad Ijaz Khan
article en

Abstract

Neurosyphilis results from infection of the nervous system by <i>Treponema pallidum</i>. The diagnosis of neurosyphilis is overlooked because of its rarity. It can manifest as early or late symptoms after primary infection with syphilis, with symptoms lying on the spectrum of asymptomatic early neurosyphilis, syphilitic meningitis, meningovascular syphilis, general paresis, and tabes dorsalis. In this report, we present a case of neurosyphilis presenting with acute confusion and agitation.

CureusVol. 17(4)
Khyber Teaching Hospital (PK), University Hospital Kerry (IE), University Hospitals Sussex NHS Foundation Trust (GB)
Zero hunger
Openalex Percentile: Top 90%
Syphilis Diagnosis and Treatment
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