Association between medication adherence and cardiovascular outcomes in patients with both diabetes and hypertension in primary care settings in Canada: A retrospective cohort study
High adherence to antidiabetic and statin monotherapy correlated with lower all-cause mortality risk and improved intermediate clinical outcomes. However, simultaneous adherence to three medications did not significantly affect CVD outcomes, but influenced intermediate outcomes. Therefore, improving adherence to antihypertensives, antidiabetics, and statins among patients with hypertension and diabetes is important in primary care settings.
Authors
- Min Su (ORCID: https://orcid.org/0000-0003-3772-1891)
- France Légaré (ORCID: https://orcid.org/0000-0002-2296-6696)
- Shishi Wu (ORCID: https://orcid.org/0000-0001-6625-2540)
- Ross Upshur (ORCID: https://orcid.org/0000-0003-1128-0557)
- Frank Sullivan
- Xiaolin Wei (ORCID: https://orcid.org/0000-0002-3076-2650)
- Michelle Greiver (ORCID: https://orcid.org/0000-0001-8957-0285)
- Xiwen Qin
- Yanhong Li (ORCID: https://orcid.org/0009-0007-8361-3310)
Institutions
- University of St Andrews (GB)
- The University of Western Australia (AU)
- University of Toronto (CA)
- Inner Mongolia University (CN)
- North York General Hospital (CA)
- Hong Kong Science and Technology Parks Corporation (HK)
- Public Health Ontario (CA)
- Université Laval (CA)
- University of Hong Kong (HK)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1371/journal.pone.0319991
- Citations
- 3
- Primary Topic
- Medication Adherence and Compliance
- Type
- article
- Field-Weighted Citation Impact
- 4.55