Sensitivity of multi-parametric quantitative magnetic resonance imaging for multiple sclerosis pathology
In our study, we successfully compared nine different quantitative MR parameters within the same subjects for tissue characterization of MS. Our study adds relevant aspects to the current debate on different sensitivities of various quantitative MR biomarkers to MS pathology. While all investigated MR biomarkers allowed characterizing lesions in individual patients, a separation of NAWM and HCWM could be most promising with the myelin-sensitive measures MWF, MTsat, and ihMTR.
Authors
- Jan S. Kirschke (ORCID: https://orcid.org/0000-0002-7557-0003)
- Aurore Menegaux (ORCID: https://orcid.org/0000-0003-3965-0396)
- Christine Preibisch (ORCID: https://orcid.org/0000-0003-4067-1928)
- Irene M. Vavasour (ORCID: https://orcid.org/0000-0001-9286-0953)
- María Guadalupe Mora Álvarez (ORCID: https://orcid.org/0000-0002-2165-6063)
- Thomas Amthor (ORCID: https://orcid.org/0000-0002-1456-6131)
- Mark Mühlau (ORCID: https://orcid.org/0000-0002-9545-2709)
- Benedikt Wiestler (ORCID: https://orcid.org/0000-0002-2963-7772)
- Ronja Berg (ORCID: https://orcid.org/0000-0003-1722-437X)
- Sarah Schlaeger
- Viola Pongratz (ORCID: https://orcid.org/0000-0003-0981-1080)
- Markus Lauerer (ORCID: https://orcid.org/0000-0002-5711-0054)
- Claus Zimmer (ORCID: https://orcid.org/0000-0002-4805-9103)
- Mariya Doneva (ORCID: https://orcid.org/0000-0003-0292-5069)
- Guillaume Gilbert (ORCID: https://orcid.org/0000-0002-9960-1062)
Institutions
- University of British Columbia (CA)
- TUM Klinikum (DE)
- LMU Klinikum (DE)
- Philips (Canada) (CA)
- Philips (Germany) (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1371/journal.pone.0318415
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Faculty of Medicine, Munich University of Technology