Bioactive compounds of Hemidesmis indices inhibit the acyl-homoserine lactone synthase

AHL (acyl homoserine lactone) is a signaling molecule responsible for communication in gram negative bacteria, which is responsible for bacterial virulence as well as biofilm formation. The speedy growing in the number of resistant pathogenic bacteria takes controlled to a decrease in the efficacy of the existing antimicrobial agents. Acyl-homoserine lactone synthase plays an important role in the key molecules responsible for the formation of antibiotic resistance of gram-negative bacteria. The molecular docking studies performed by using molecular docking server online respectively in which the oral biofilm target namely N-acyl homoserine (ESAI) (PDB id: 1kzf) have a potential interaction with vanillin and Hexadeconoic acid. In this study, the protein N-acyl homoserine (ESAI) was used from its structure perspectives. The primary and secondary structures were calculated using online tools. Its role in oral biofilm was assessed by molecular docking the compounds present in the root extract of Hemidesmis indices assayed by GC-MS analysis. This in-silico study results throw light on how these active components of Hemidesmis indices are effective in oral biofilm. Keywords: Hemidesmis indices, Docking studies.