Formulation and Evaluation of Guava Leaf-Based Nanogel for Mouth Ulcer Treatment

Mouth ulcers, also known as aphthous ulcers, are painful lesions affecting the oral mucosa, causing discomfort and irritation. Conventional treatments, such as antiseptic gels and corticosteroids, provide temporary relief but may have side effects with prolonged use. Guava leaves (Psidium guajava) contain bioactive compounds such as flavonoids, tannins, and polyphenols, which exhibit antimicrobial, anti-inflammatory, and wound-healing properties. This study focuses on the formulation of a simple, Nanogel using Carbopol 934 as a base for the treatment of mouth ulcers. The gel was prepared by incorporating guava leaf extract into a Carbopol-based gel matrix and was evaluated for pH, viscosity, spreadability, drug content, and stability. The formulation showed good Nanogel properties, proper viscosity, and a suitable pH 6.5-7.5, making it safe and effective for oral application. This study suggests that a guava leaf-based Nanogel can be a natural, cost-effective alternative for mouth ulcer treatment. Keywords: Mouth ulcer, Guava leaf extract, Nanogel gel, Carbopol 934