Scutellaria Barbata inhibits epithelial-mesenchymal transformation through PI3K/AKT and MDM2 thus inhibiting the proliferation, migration and promoting apoptosis of Cervical Cancer cells
After combining with EGFR, TNF-α and VEGFA, the active ingredient of Sculellaria Barbata can regulate the PI3K/AKT signaling pathway and down-regulate the expression of MDM2 gene to inhibit the epithelial-mesenchymal transition, which can inhibit cervical cancer cell proliferation, migration, and promote their apoptosis. Sculellaria Barbata is a potential therapeutic candidate for cervical cancer.
Authors
- Congchao Jia (ORCID: https://orcid.org/0000-0001-7748-2448)
- Wen-Qi Feng (ORCID: https://orcid.org/0000-0003-1181-5590)
- Guobing Wang (ORCID: https://orcid.org/0000-0001-8362-9186)
- Lei Liang
- Lan Li (ORCID: https://orcid.org/0000-0002-4657-0864)
- Dexin Wang (ORCID: https://orcid.org/0000-0003-1120-0131)
- Gang Tian (ORCID: https://orcid.org/0000-0001-7301-5949)
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- First Affiliated Hospital of Sichuan Medical University (CN)
- Yibin University (CN)
- Second People’s Hospital of Yibin (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1371/journal.pone.0321556
- Citations
- 1
- Primary Topic
- Flavonoids in Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39