Earlier onset of chemotherapy-induced neuropathic pain in females by ICAM-1–mediated accumulation of perivascular macrophages

Sex differences in the pathogenesis of a variety of diseases have drawn increasing attention. However, it remains unclear whether such differences exist in chemotherapy-induced neuropathic pain. Here, we conducted a retrospective analysis of clinical case data and found that peripheral sensory disorders occurred earlier in females than in males following bortezomib (BTZ) treatment in patients with multiple myeloma. BTZ treatment led to an early elevation of intercellular adhesion molecule-1, which triggered the infiltration of peripheral monocytes into the perivascular region of the spinal cord in female mice. The CC-chemokine ligand 1 released by infiltrating macrophages directly activated neurons or indirectly activated neurons by enhancing the astrocyte activity, ultimately leading to the earlier onset of BTZ-induced neuropathic pain in females. Together, clarifying the mechanism underlying the earlier onset of BTZ-induced neuropathic pain will contribute to the precise treatment of multiple myeloma in females.

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Publication Details

Journal
Science Advances
Published
2025-04-16
DOI
https://doi.org/10.1126/sciadv.adu2159
Citations
5
Primary Topic
Pain Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
5.82
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article

Earlier onset of chemotherapy-induced neuropathic pain in females by ICAM-1–mediated accumulation of perivascular macrophages

Ting Xu, Wen‐Jun Xin, Muyang Chen, Xia Feng et al.
5 citations
Science Advances
Pain Mechanisms and Treatments
5.82
article

Earlier onset of chemotherapy-induced neuropathic pain in females by ICAM-1–mediated accumulation of perivascular macrophages

Ting Xu, Wen‐Jun Xin, Muyang Chen, Xia Feng, Jingdun Xie, Xiao‐Qing Tang, Chen Wang, Li Chen, Xin Zou, Cuicui Liu, Jingming Shi, Xiangzhong Zhang, Pu Yan, Jie Deng
article en
5 citations

Abstract

Sex differences in the pathogenesis of a variety of diseases have drawn increasing attention. However, it remains unclear whether such differences exist in chemotherapy-induced neuropathic pain. Here, we conducted a retrospective analysis of clinical case data and found that peripheral sensory disorders occurred earlier in females than in males following bortezomib (BTZ) treatment in patients with multiple myeloma. BTZ treatment led to an early elevation of intercellular adhesion molecule-1, which triggered the infiltration of peripheral monocytes into the perivascular region of the spinal cord in female mice. The CC-chemokine ligand 1 released by infiltrating macrophages directly activated neurons or indirectly activated neurons by enhancing the astrocyte activity, ultimately leading to the earlier onset of BTZ-induced neuropathic pain in females. Together, clarifying the mechanism underlying the earlier onset of BTZ-induced neuropathic pain will contribute to the precise treatment of multiple myeloma in females.

Science AdvancesVol. 11(16)
Sun Yat-sen University (CN), Xizang Minzu University (CN), Longgang Central Hospital (CN), Sun Yat-sen Memorial Hospital (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), Sun Yat-sen University Cancer Center (CN), Third Affiliated Hospital of Sun Yat-sen University (CN), University of South China (CN)
Good health and well-being
Openalex Percentile: Top 4%
Pain Mechanisms and Treatments
5.82
DOIOpen Access PDFOpenAlex
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