Different cutoff values of the skeletal muscle mass and myosteatosis result in different clinical impact on overall survival in oncology. A subanalysis of a clinical trial
The large variability in prevalence and prognostic impact observed across different cutoff definitions underscores the urgent need for standardized, cancer-specific cutoff values for SMI and muscle attenuation. Establishing uniform criteria will enhance the reliability and clinical applicability of body composition metrics as prognostic tools in oncology. Further research should focus on refining these cutoffs and validating them across diverse cancer populations.
Authors
- Andreas Wienke (ORCID: https://orcid.org/0000-0002-8927-6534)
- Jens Ricke (ORCID: https://orcid.org/0000-0001-8762-8594)
- Maximilian Thormann (ORCID: https://orcid.org/0000-0003-3822-8871)
- Max Seidensticker (ORCID: https://orcid.org/0000-0002-2481-5410)
- Alexey Surov
Institutions
- University Hospitals of the Ruhr-University of Bochum (DE)
- LMU Klinikum (DE)
- University Hospital in Halle (DE)
- Ludwig-Maximilians-Universität München (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1007/s00432-025-06190-1
- Citations
- 6
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- Charité – Universitätsmedizin Berlin