Rapid and modular synthesis of skeletally diverse natural product analogs by expansion of biosynthetic processes

Abstract At the forefront of advanced biomimetic synthetic pathways, our research group transcends traditional single-target synthetic campaigns by developing versatile chemical assembly lines. These transformative synthetic approaches enable the rapid, modular construction of a wide range of structurally diverse natural products and their derivatives. This review primarily addresses 2 approaches: (i) a chemo-enzymatic synthetic process and (ii) a biogenetically inspired synthesis of skeletally diverse natural products and their variants. Together, these complementary strategies facilitate the development of streamlined modular assembly lines that are capable of systematically generating “scaffold variations.” Our explorations are shaping innovative synthetic tactics that provide rapid, cost-effective, and flexible access to the expansive realm of natural product-relevant chemical space.

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Publication Details

Journal
Bulletin of the Chemical Society of Japan
Published
2025-04-16
DOI
https://doi.org/10.1093/bulcsj/uoaf036
Citations
1
Primary Topic
Microbial Natural Products and Biosynthesis
Type
article
Field-Weighted Citation Impact
1.39

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article

Rapid and modular synthesis of skeletally diverse natural product analogs by expansion of biosynthetic processes

Hiroki Oguri
1 citations
Bulletin of the Chemical Society of Japan
Microbial Natural Products and Biosynthesis
1.39
article

Rapid and modular synthesis of skeletally diverse natural product analogs by expansion of biosynthetic processes

Hiroki Oguri
article en
1 citations

Abstract

Abstract At the forefront of advanced biomimetic synthetic pathways, our research group transcends traditional single-target synthetic campaigns by developing versatile chemical assembly lines. These transformative synthetic approaches enable the rapid, modular construction of a wide range of structurally diverse natural products and their derivatives. This review primarily addresses 2 approaches: (i) a chemo-enzymatic synthetic process and (ii) a biogenetically inspired synthesis of skeletally diverse natural products and their variants. Together, these complementary strategies facilitate the development of streamlined modular assembly lines that are capable of systematically generating “scaffold variations.” Our explorations are shaping innovative synthetic tactics that provide rapid, cost-effective, and flexible access to the expansive realm of natural product-relevant chemical space.

Bulletin of the Chemical Society of JapanVol. 98(5)
The University of Tokyo (JP)
Sumitomo Foundation, Japan Foundation of Applied Enzymology, Showa Pharmaceutical University, University of Toyama, Ministry of Education, Culture, Sports, Science and Technology, Astellas Pharma, Shionogi, Mochida Memorial Foundation for Medical and Pharmaceutical Research, Daiichi Sankyo Foundation of Life Science, Hokkaido University, Astellas Foundation for Research on Metabolic Disorders, Northern Advancement Center for Science and Technology, Kitasato University, Tokyo University of Agriculture, Soochow University, Tokyo University of Agriculture and Technology, Global Health Innovative Technology Fund, Japan Society for the Promotion of Science, Precursory Research for Embryonic Science and Technology, Science and Technology Research Partnership for Sustainable Development, Daiichi Sankyo Europe
Openalex Percentile: Top 21%
Microbial Natural Products and Biosynthesis
1.39
DOIOpen Access PDFOpenAlex
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