Quantitative MRI detects delayed perfusion and impact of bronchial artery dilatation on pulmonary circulation in patients with cystic fibrosis
Question Dilated bronchial arteries are a common comorbidity in cystic fibrosis (CF), which can cause hemoptysis, but their quantitative contribution to lung perfusion is little researched. Findings Perfusion defects in percent (QDP) enabled objective assessment of perfusion abnormalities in CF patients, while perfusion delay and arterial correlation showed bronchial artery perfusion contribution. Clinical relevance The usage of quantitative perfusion metrics in CF may help tracking disease progression. By also including the proposed metrics perfusion delay and arterial correlation, bronchial artery inflow could be assessed and used to detect early onset of bronchial artery dilation.
Authors
- Mark Oliver Wielpütz (ORCID: https://orcid.org/0000-0001-6962-037X)
- Simon M. F. Triphan (ORCID: https://orcid.org/0000-0003-2068-1184)
- Olaf Sommerburg (ORCID: https://orcid.org/0000-0002-3941-8944)
- Patricia Leutz-Schmidt (ORCID: https://orcid.org/0000-0003-3860-7652)
- Michael E. Selzer (ORCID: https://orcid.org/0000-0002-1141-217X)
- Marcus Alexander Mall (ORCID: https://orcid.org/0000-0002-4057-2199)
- Britta Nestler
- Simon Y. Graeber (ORCID: https://orcid.org/0000-0002-1666-8924)
- Jens‐Peter Schenk (ORCID: https://orcid.org/0000-0002-0588-0225)
- Mirjam Stahl (ORCID: https://orcid.org/0000-0001-6941-8315)
- Sabine Wege
- Arnd Koeppe (ORCID: https://orcid.org/0000-0002-4833-1306)
- Monika Eichinger
- Lena Wucherpfennig (ORCID: https://orcid.org/0000-0002-2280-1269)
- Abdulsattar Alrajab
- Hans‐Ulrich Kauczor
- Julian Grolig
Institutions
- Karlsruhe Institute of Technology (DE)
- Heidelberg University (DE)
- Universitätsmedizin Greifswald (DE)
- University Hospital Heidelberg (DE)
- German Centre for Cardiovascular Research (DE)
- German Center for Lung Research (DE)
- Karlsruhe University of Applied Sciences (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- European Radiology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1007/s00330-025-11589-y
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Helmholtz Association