Superimposed Effect of Intramolecular Modular Assembling and Silver Coordination to Amplify Superoxide Anion Radical for Antitumor and Antibacterial Photodynamic therapy

Photodynamic therapy (PDT) calls for highly efficient photosensitizers with a Type I mechanism to overcome the limitation of the hypoxic microenvironment, which exists in both tumor tissues and bacterial infection sites. However, the rational design of Type I PDT photosensitizers is still a challenging goal. Herein, a dyad photosensitizer is developed based on an intramolecular modular assembling strategy to produce superoxide anion radical via a Type I mechanism. Further, the superoxide anion radical amplification is superimposed by silver coordination. In vitro and in vivo antitumor and antibacterial PDT experiments demonstrated the superimposed effect on superoxide anion radical amplification. This work opens a window to rationally design Type I PDT photosensitizers.

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Publication Details

Journal
ACS Materials Letters
Published
2025-04-16
DOI
https://doi.org/10.1021/acsmaterialslett.5c00381
Citations
1
Primary Topic
Nanoplatforms for cancer theranostics
Type
article
Field-Weighted Citation Impact
0.67

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article

Superimposed Effect of Intramolecular Modular Assembling and Silver Coordination to Amplify Superoxide Anion Radical for Antitumor and Antibacterial Photodynamic therapy

Yingnan Wu, Meng Zhou, Fengling Song, Gaobo Hong et al.
1 citations
ACS Materials Letters
Nanoplatforms for cancer theranostics
0.67
article

Superimposed Effect of Intramolecular Modular Assembling and Silver Coordination to Amplify Superoxide Anion Radical for Antitumor and Antibacterial Photodynamic therapy

Yingnan Wu, Meng Zhou, Fengling Song, Gaobo Hong, Haoran Hou, Wenlong Chen, Dapeng Liu, Siwen Wei
article en
1 citations

Abstract

Photodynamic therapy (PDT) calls for highly efficient photosensitizers with a Type I mechanism to overcome the limitation of the hypoxic microenvironment, which exists in both tumor tissues and bacterial infection sites. However, the rational design of Type I PDT photosensitizers is still a challenging goal. Herein, a dyad photosensitizer is developed based on an intramolecular modular assembling strategy to produce superoxide anion radical via a Type I mechanism. Further, the superoxide anion radical amplification is superimposed by silver coordination. In vitro and in vivo antitumor and antibacterial PDT experiments demonstrated the superimposed effect on superoxide anion radical amplification. This work opens a window to rationally design Type I PDT photosensitizers.

ACS Materials LettersVol. 7(5)
Shandong University (CN), Shenzhen University (CN), Dalian University of Technology (CN), Smart Material (Germany) (DE), Division of Materials Science and Engineering (AU), State Key Laboratory of Fine Chemicals
Science and Technology Foundation of Shenzhen City, National Natural Science Foundation of China, China Postdoctoral Science Foundation, Natural Science Foundation of Shandong Province, Basic and Applied Basic Research Foundation of Guangdong Province
Zero hunger
Openalex Percentile: Top 33%
Nanoplatforms for cancer theranostics
0.67
DOISourceOpenAlex
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Superimposed Effect of Intramolecular Modular Assembling and Silver Coordination to Amplify Superoxide Anion Radical for Antitumor and Antibacterial Photodynamic therapy — Yingnan Wu, Meng Zhou, et al. · ACS Materials Letters (2025) | TGRS Research Map | TGRS