Feasibility assessment of radiolabeled FAPI-04 for diagnostic and therapeutic use in rheumatoid arthritis
Radiotracer <sup>68</sup>Ga-FAPI-04 effectively targets FAPα, enabling PET imaging to identify CIA severity and onset sites in mice. Additionally, <sup>177</sup>Lu-FAPI-04 demonstrated therapeutic potential by mitigating disease activity, suggesting its promise for RA treatment.
Authors
- Yun-Chen Tsai (ORCID: https://orcid.org/0000-0003-1726-8882)
- Wen-Yi Tseng
- Yun-Ju Huang (ORCID: https://orcid.org/0000-0002-6226-6635)
- Ling‐Shan Yu (ORCID: https://orcid.org/0000-0001-7300-4393)
- Yi‐Sheng Chan (ORCID: https://orcid.org/0000-0001-7413-1431)
- Kuang‐Hui Yu (ORCID: https://orcid.org/0000-0001-6251-0231)
- Yeong‐Jian Jan Wu (ORCID: https://orcid.org/0000-0002-5444-4729)
- Hsi‐Hsien Lin (ORCID: https://orcid.org/0000-0003-2798-3855)
- Yi-Shu Huang (ORCID: https://orcid.org/0000-0001-8770-9298)
- Hong‐Yi Chen (ORCID: https://orcid.org/0000-0002-0457-9895)
- Shue‐Fen Luo
- Richard Williams (ORCID: https://orcid.org/0000-0002-0920-1103)
- Shih‐Che Hung
- Chang‐Fu Kuo
- C Y Hsieh
Institutions
- National Sun Yat-sen University (TW)
- Chang Gung University (TW)
- Chang Gung Memorial Hospital (TW)
- Kennedy Center (DK)
- Keelung Chang Gung Memorial Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1016/j.biopha.2025.118048
- Citations
- 3
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 3.14