Fused Tricyclic Naphthalene Lactones and a Xanthone from Ventilago maingayi and their Anti-HIV-1 Activity
Three previously undescribed compounds, including two fused tricyclic naphthalene lactones (ventilaganones A and B, 1: and 2: ) and a xanthone (ventilagoxanthone, 3: ), along with eight known compounds (4: -11: ), were isolated from the bark of <i>Ventilago maingayi</i>. Their structures were elucidated by extensive analysis of their spectroscopic data and by comparison with those of related compounds reported in the literature. The absolute configuration of ventilaganone A (1: ) was established by single-crystal X-ray analysis. Anti-HIV-1 activity of the isolated compounds was evaluated with a reverse transcriptase (RT) assay and a syncytium reduction assay using the <sup>ΔTat/Rev</sup>MC99 virus in the 1A2 cell line. Compounds 1, 2, 4, 5: , and 8-11: showed inhibitory activity against syncytium formation, while most compounds were found to be inactive in the reverse transcriptase assay.
Authors
- Arthit Chairoungdua (ORCID: https://orcid.org/0000-0002-0965-126X)
- Ponsiri Liangsakul
- Chutima Kuhakarn (ORCID: https://orcid.org/0000-0003-4638-4356)
- Siriporn Jungsuttiwong (ORCID: https://orcid.org/0000-0001-5943-6878)
- Sariyarach Thanasansurapong (ORCID: https://orcid.org/0000-0001-9775-7445)
- Narong Nuntasaen (ORCID: https://orcid.org/0000-0002-5870-3329)
- Ratchadaree Intayot (ORCID: https://orcid.org/0000-0002-2158-7854)
- Sakchai Hongthong (ORCID: https://orcid.org/0000-0001-5138-7530)
- Vichai Reutrakul (ORCID: https://orcid.org/0000-0002-0743-1300)
- Radeekorn Akkarawongsapat
Institutions
- Kasetsart University (TH)
- Mahidol University (TH)
- Centre of Excellence in Mathematics (TH)
- Rajabhat Rajanagarindra University (TH)
- Ubon Ratchathani University (TH)
Publication Details
- Journal
- Planta Medica
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1055/a-2589-5900
- Primary Topic
- Plant Toxicity and Pharmacological Properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00