Comparative analysis of β-Estradiol and testosterone on lipid droplet accumulation, and regulatory protein expression in palmitate/oleate-induced fatty HepG2 cells
This study demonstrates that β-estradiol and testosterone significantly modulate LD content and the expression of key regulatory genes in HepG2 cells, with β-estradiol showing a somewhat dominant role in enhancing lipid turnover and mitigating lipid accumulation.
Authors
- Motaharesadat Hosseini (ORCID: https://orcid.org/0000-0003-1092-1893)
- Zahra Rezaei (ORCID: https://orcid.org/0000-0002-5060-7500)
- Elham Bahreini (ORCID: https://orcid.org/0000-0001-6823-8638)
- Iraj Alipourfard (ORCID: https://orcid.org/0000-0001-5164-8606)
- Fereshteh Barjesteh
- Fereshteh Azedi (ORCID: https://orcid.org/0000-0001-9776-7686)
Institutions
- Iran University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
- University of Silesia in Katowice (PL)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s12876-025-03863-6
- Citations
- 4
- Primary Topic
- Lipid metabolism and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 4.45
Funders
- Iran University of Medical Sciences