Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation
Together these results suggest a biphasic trajectory for 5-hydroxymethyation dynamics that has bearing on potential therapeutic interventions aimed at manipulating 5-hydroxymethylcytosine levels.
Authors
- Ben Murcott
- Adele Murrell (ORCID: https://orcid.org/0000-0003-2647-3511)
- David Gurevich (ORCID: https://orcid.org/0000-0002-7194-7520)
- Thérèse Dix‐Peek (ORCID: https://orcid.org/0000-0002-7593-0857)
- Joanne Robson (ORCID: https://orcid.org/0000-0003-0157-1692)
- Piotr Manasterski (ORCID: https://orcid.org/0000-0002-8700-5458)
- Floris Honig (ORCID: https://orcid.org/0000-0002-6006-7376)
- Santiago Uribe‐Lewis (ORCID: https://orcid.org/0000-0002-2801-360X)
- Julia Sero (ORCID: https://orcid.org/0000-0002-0299-9212)
- Dominic Oliver Halliwell (ORCID: https://orcid.org/0000-0003-2848-7888)
- Yuan Tian (ORCID: https://orcid.org/0000-0003-1312-6166)
- Ashraf E.K. Ibrahim
- Nikolas Nikolaou (ORCID: https://orcid.org/0000-0002-4164-0915)
- Jennifer Pinnell
Institutions
- University of the West of England (GB)
- University of the Witwatersrand (ZA)
- University of Exeter (GB)
- Royal Surrey County Hospital (GB)
- Peterborough City Hospital (GB)
- Edinburgh Cancer Research (GB)
- Public Library of Science (GB)
- Royal Surrey NHS Foundation Trust (GB)
- CRUK Lung Cancer Centre of Excellence (GB)
- University College London (GB)
- University of Bath (GB)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s12915-025-02205-y
- Citations
- 4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Royal Society
- Academy of Medical Sciences
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Biotechnology and Biological Sciences Research Council
- Menzies Centre for Australian Studies, King's College London, University of London