Gut microbiota contributes to obstructive sleep apnea-induced hypertension by gut-heart axis in mice
This study demonstrates the pro-hypertensive effects of gut microbiota in OSA, mediated through the gut-derived LPS/TLR4/NF-κB pathway. These findings may guide the development of therapeutic strategies focused on restoring gut microbiome homeostasis.
Authors
- Qiang Wang (ORCID: https://orcid.org/0000-0003-2939-3322)
- Si Shen
- Yongjun Chen (ORCID: https://orcid.org/0000-0001-6587-7581)
- Xiaotong Zhang (ORCID: https://orcid.org/0000-0002-2852-9884)
- Yanran Yin
- Fan Fang
- Linghang Lin
Institutions
- Shanxi Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1016/j.intimp.2025.114667
- Citations
- 5
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 5.82