The burden and diagnostic challenges of subclinical Plasmodium falciparum infections in Southern Ghana
The high prevalence of subclinical malaria infections is likely to be a potential reservoir in sustaining malaria transmission. HRP2-based RDTs detected two-thirds of the subclinical infections. Given the absence of hrp2 deletions, community testing and treatment programs using highly sensitive HRP2-based RDTs could be a valuable strategy in detecting the parasite reservoir and potentially help in ensuring a sustainable decline in disease transmission.
Authors
- Thomas Kwame Addison
- Stephen Opoku Afriyie (ORCID: https://orcid.org/0000-0002-8334-5332)
- Abraham K. Badu‐Tawiah (ORCID: https://orcid.org/0000-0001-8642-3431)
- Claudia A. Vera-Arias (ORCID: https://orcid.org/0009-0004-7835-2644)
- Emma V. Troth (ORCID: https://orcid.org/0000-0002-5879-7695)
- Kwasi Baako Antwi
- Matthew Glover Addo (ORCID: https://orcid.org/0000-0002-0031-8233)
- Abdul‐Hakim Mutala (ORCID: https://orcid.org/0000-0002-2556-6823)
- Kingsley Badu (ORCID: https://orcid.org/0000-0002-7886-5528)
- Cristian Koepfli (ORCID: https://orcid.org/0000-0002-9354-0414)
Institutions
- University of Notre Dame (US)
- Kwame Nkrumah University of Science and Technology (GH)
- The Ohio State University (US)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s12879-025-10897-4
- Citations
- 2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Bill and Melinda Gates Foundation
- National Institute of Allergy and Infectious Diseases
- European and Developing Countries Clinical Trials Partnership