Development and Validation of an Artificial Intelligence Digital Pathology Biomarker to Predict Benefit of Long-Term Hormonal Therapy and Radiotherapy in Men With High-Risk Prostate Cancer Across Multiple Phase III Trials
To our knowledge, the MMAI model is the first validated predictive biomarker to guide ADT duration with RT in localized/locally advanced PCa. Approximately one third of men with high-risk PCa could safely be spared the additional 24 months of ADT and the associated morbidity.
Authors
- Joseph P. Rodgers
- Jacqueline Griffin (ORCID: https://orcid.org/0000-0002-3928-3891)
- Osama Mohamad (ORCID: https://orcid.org/0000-0003-2972-657X)
- Paul Linh Nguyen (ORCID: https://orcid.org/0000-0003-4268-3973)
- Felix Yi-Chung Feng (ORCID: https://orcid.org/0000-0002-0963-7687)
- Todd Matthew Morgan (ORCID: https://orcid.org/0000-0002-1140-0603)
- Jeffry Simko
- Ali El‐Gayed (ORCID: https://orcid.org/0000-0002-4581-2892)
- Andrew J. Armstrong (ORCID: https://orcid.org/0000-0001-7012-1754)
- Emmalyn Chen
- Howard M. Sandler (ORCID: https://orcid.org/0000-0002-8193-5769)
- Rikiya Yamashita (ORCID: https://orcid.org/0000-0002-2686-2333)
- Elizabeth Gore
- Rana R. McKay (ORCID: https://orcid.org/0000-0002-0581-7963)
- Steve P. Lee (ORCID: https://orcid.org/0000-0001-7168-1542)
- Jedidiah M. Monson
- Andre Esteva (ORCID: https://orcid.org/0000-0003-1937-9682)
- Phuoc T. Tran (ORCID: https://orcid.org/0000-0002-0147-0376)
- Oliver A. Sartor (ORCID: https://orcid.org/0000-0002-8777-7343)
- Daniel Eidelberg Spratt (ORCID: https://orcid.org/0000-0002-5973-4741)
- Mark E. Augspurger
- Vinnie Y.T. Liu (ORCID: https://orcid.org/0000-0002-7152-6830)
- Huei–Chung Huang
- Christopher A. Peters
- Sandy DeVries
- John H. Carson
- Ramprasaath R. Selvaraju
Institutions
- American College of Radiology (US)
- University of Maryland, Baltimore (US)
- Cedars-Sinai Medical Center (US)
- Brigham and Women's Hospital (US)
- University of California, San Francisco (US)
- Clarkson College (US)
- Medical College of Wisconsin (US)
- University of Michigan (US)
- University of California San Diego (US)
- Community Health Systems - Regional Hospital of Scranton (US)
- Saint Agnes Medical Center (US)
- Milwaukee VA Medical Center (US)
- Mayo Clinic in Arizona (US)
- Duke Medical Center (US)
- Baptist Medical Center Jacksonville (US)
- VA Long Beach Healthcare System (US)
- Northeast Radiation Oncology Center (US)
- NRG Oncology (US)
- Artistic Realization Technologies (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1200/jco.24.00365
- Citations
- 15
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 22.78