Association of Nonmodifiable Risk Factors With Alzheimer Disease Blood Biomarkers in Community-Dwelling Adults in the ESTHER Study
This population-based study on dementia biomarkers found that P-tau181 was dependent on age and <i>APOEe4</i>; NfL on age and sex; and GFAP on age, sex, <i>APOEe4</i>, and menopause status. GFAP levels and rate of increase were higher in women, especially in premenopausal participants. Future research should confirm these findings and further explore the role of menopause in dementia pathogenesis among women.
Authors
- Kira Trares (ORCID: https://orcid.org/0000-0002-1775-3231)
- Bernd Holleczek
- Joshua Stevenson‐Hoare (ORCID: https://orcid.org/0000-0002-6823-5469)
- Dan Rujescu (ORCID: https://orcid.org/0000-0002-1432-313X)
- Ben Schoettker
- Hannah Stocker (ORCID: https://orcid.org/0000-0001-5281-2455)
- Léon Beyer (ORCID: https://orcid.org/0000-0002-5889-6044)
- Hermann Brenner (ORCID: https://orcid.org/0000-0002-6129-1572)
- Klaus Gerwert (ORCID: https://orcid.org/0000-0001-8759-5964)
- Konrad Beyreuther
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Krebsregister Saarland (DE)
- Medical University of Vienna (AT)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1212/wnl.0000000000213500
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41