White Matter Tract Degeneration in Multiple Sclerosis Patients With Progression Independent of Relapse Activity
Our findings highlight an association between PIRA and microstructural damage in key WM tracts. The observed DTI changes likely reflect processes such as Wallerian degeneration and contribute to the growing evidence linking PIRA to neurodegeneration.
Authors
- Sabine Schädelin (ORCID: https://orcid.org/0000-0002-1150-0962)
- Alessandro Cagol (ORCID: https://orcid.org/0000-0002-7703-0553)
- Jens Kühle (ORCID: https://orcid.org/0000-0002-6963-8892)
- Jannis Müller (ORCID: https://orcid.org/0000-0003-1394-8231)
- Po‐Jui Lu (ORCID: https://orcid.org/0000-0001-6031-6865)
- Ludwig Kappos (ORCID: https://orcid.org/0000-0003-4175-5509)
- Matthias Weigel (ORCID: https://orcid.org/0000-0002-4910-1414)
- Maria Pia Sormani (ORCID: https://orcid.org/0000-0001-6892-104X)
- Muhamed Baraković (ORCID: https://orcid.org/0000-0001-8557-9223)
- Pascal Benkert (ORCID: https://orcid.org/0000-0001-6525-8174)
- Mario Ocampo‐Pineda (ORCID: https://orcid.org/0000-0003-2239-7355)
- Cristina Granziera (ORCID: https://orcid.org/0000-0002-4917-8761)
- Lester Melie‐García (ORCID: https://orcid.org/0000-0001-5602-8916)
Institutions
- University of Basel (CH)
- University Hospital of Basel (CH)
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1212/nxi.0000000000200388
- Citations
- 3
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.41