Deficiency of IL-7R attenuates abdominal aortic aneurysms in mice by inhibiting macrophage polarization towards M1 phenotype through the NF-κB pathway
In short, this study showed that IL-7R promotes the infiltration and migration of macrophages by regulating M1 macrophage polarization, possibly in part via activation of the NF-κB pathway, which may be associated with the development of AAAs.
Authors
- Bo Yang (ORCID: https://orcid.org/0000-0002-2158-9155)
- Yi Yu (ORCID: https://orcid.org/0000-0003-2340-5177)
- Bo Shen (ORCID: https://orcid.org/0000-0002-5701-4652)
- Xin Liu (ORCID: https://orcid.org/0000-0002-9105-317X)
- Xueyu Han
- Shengnan Xu (ORCID: https://orcid.org/0009-0009-4368-0580)
- Chuan Qu (ORCID: https://orcid.org/0000-0003-2237-1868)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Hubei University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s10020-025-01209-2
- Citations
- 2
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China