Power analysis for concurrent balanced or imbalanced multiple-intervention stepped wedge design: a simulation-based approach
When two treatment effects differ greatly, the concurrent imbalanced M-SWD, with an allocation ratio no larger than 4:1, is a preferred design over the balanced one. For both concurrent balanced and imbalanced M-SWD, it is recommended to set large number of clusters with small cluster sizes and to carefully consider estimates of correlation parameters when designing the trial.
Authors
- Wen Ling Chen (ORCID: https://orcid.org/0000-0002-6839-8890)
- Meng Zheng
- Qi Wang (ORCID: https://orcid.org/0000-0001-5511-5284)
- Chao Zhang (ORCID: https://orcid.org/0000-0003-4167-4872)
- Tingting Guo (ORCID: https://orcid.org/0009-0009-2547-0256)
- Kunpeng Wu
- Xuezhi Liang
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s12874-025-02546-w
- Primary Topic
- Mechanical Engineering and Vibrations Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Medical Board
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province for Distinguished Young Scholars
- Basic and Applied Basic Research Foundation of Guangdong Province