Successful assisted pregnancy outcome in a patient with POEMS syndrome

POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma cell disorder and Skin changes) syndrome is a rare paraneoplastic syndrome caused by a clone of aberrant plasma cells, mostly prevalent in middle-aged men. This is very rare, especially in women of reproductive age group. We are presenting a rare case of POEMS syndrome in pregnancy, who suffered from a full-blown picture of the multisystem involvement of hypothyroidism, hyperprolactinaemia, Empty Sella syndrome leading to panhypopituitarism and benign intracranial hypertension, peripheral neuropathy with trigeminal neuralgia and adrenal insufficiency. She was treated with autologous stem cell transplantation with adjuvant chemotherapy. This case report is a detailed description of the journey from in vitro fertilisation to delivery, the numerous challenges faced and how this was managed with the help of a multidisciplinary involvement to provide optimum perinatal outcome for the patient. Lack of any proper guideline about management of this rare syndrome in pregnancy made this more challenging.