Integrating TSPO-PET imaging with metabolomics for enhanced prognostic accuracy in multiple sclerosis
Measuring three specific serum metabolites is as effective as TSPO imaging in predicting MS progression. However, integrating TSPO imaging with serum metabolite analysis substantially enhances predictive accuracy. Given the simplicity and affordability of NMR analysis, this approach could lead to more personalised, accessible treatment strategies and serve as a valuable tool for clinical trial stratification.
Authors
- Daniel C. Anthony (ORCID: https://orcid.org/0000-0003-1380-6655)
- Abi G. Yates (ORCID: https://orcid.org/0000-0002-8501-2160)
- Laura M. Airas (ORCID: https://orcid.org/0000-0002-9751-5881)
- Eline Willemse (ORCID: https://orcid.org/0009-0009-8093-8755)
- Jens Kühle (ORCID: https://orcid.org/0000-0002-6963-8892)
- Marjo Nylund (ORCID: https://orcid.org/0000-0001-6695-5684)
- Marcus Sucksdorff (ORCID: https://orcid.org/0000-0003-0432-2931)
- Tereza Kačerová (ORCID: https://orcid.org/0000-0002-9477-0182)
- Daniel Radford‐Smith (ORCID: https://orcid.org/0000-0001-8781-7459)
- Fay Probert (ORCID: https://orcid.org/0000-0002-8580-2023)
- Markus Matilainen (ORCID: https://orcid.org/0000-0002-5597-2670)
- David Leppert (ORCID: https://orcid.org/0000-0001-6172-801X)
- Aleksandra Maleska Maceski (ORCID: https://orcid.org/0000-0002-1916-5927)
- Johanna Oechtering (ORCID: https://orcid.org/0000-0001-5359-7961)
Institutions
- University of Turku (FI)
- Turku University of Applied Sciences (FI)
- University of Basel (CH)
- Turku University Hospital (FI)
- University Hospital of Basel (CH)
- University of Oxford (GB)
- Turku PET Centre (FI)
Publication Details
- Journal
- BMJ Neurology Open
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/bmjno-2025-001026
- Citations
- 5
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- Suomen Lääketieteen Säätiö
- Finska Läkaresällskapet
- Academy of Finland
- Engineering and Physical Sciences Research Council