Morbidity-bridging metabolic pathways: linking early cardiovascular disease risk and depression symptoms using a multi-modal approach
This study integrated three statistical techniques and identified two metabolic markers (glucose, omega-3 FAs) connecting depression and CVD on a symptom and risk factor level. The associations, established in a relatively young cohort, were replicated in a predominantly middle-aged cohort and emphasize both the generalizability of the findings across different populations and value of symptom-level analysis in depression and CVD comorbidity research.
Authors
- Jos A. Bosch (ORCID: https://orcid.org/0000-0001-7780-4806)
- Mika A. P. Kähönen (ORCID: https://orcid.org/0000-0002-4510-7341)
- Arja O. Rydin (ORCID: https://orcid.org/0000-0002-5525-3350)
- Yuri Milaneschi (ORCID: https://orcid.org/0000-0002-3697-6617)
- Sander W. van der Laan (ORCID: https://orcid.org/0000-0001-6888-1404)
- Dimitrios I. Fotiadis (ORCID: https://orcid.org/0000-0002-5987-9350)
- Pashupati P. Mishra (ORCID: https://orcid.org/0000-0001-5177-3431)
- Olli T. Raitakari (ORCID: https://orcid.org/0000-0001-9365-3702)
- Rick Quax (ORCID: https://orcid.org/0000-0002-0299-0074)
- Femke Lamers (ORCID: https://orcid.org/0000-0003-4344-5766)
- Terho J. Lehtimäki (ORCID: https://orcid.org/0000-0002-2555-4427)
- Angela Koloi (ORCID: https://orcid.org/0009-0001-8197-3749)
- Emma Pruin (ORCID: https://orcid.org/0009-0001-9702-4185)
Institutions
- Tampere University of Applied Sciences (FI)
- University of Turku (FI)
- Tampere University (FI)
- Utrecht University (NL)
- University of Ioannina (GR)
- Turku University Hospital (FI)
- University Medical Center Utrecht (NL)
- Amsterdam Neuroscience (NL)
- Tampere University Hospital (FI)
- Cardiovascular Research Center (BR)
- Tampere University (FI)
- Fimlab (Finland) (FI)
- Biomedical Research Institute (US)
- GGD Amsterdam (NL)
- Public Health Service of Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- Institute of Informatics of the Slovak Academy of Sciences (SK)
- University of Virginia (US)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- Foundation for Research and Technology Hellas (GR)
Publication Details
- Journal
- European Heart Journal Open
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1093/ehjopen/oeaf038
- Citations
- 1
- Primary Topic
- Cardiovascular Health and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Foundation for Cardiovascular Research
- Yrjö Jahnssonin Säätiö
- European Commission
- Kela
- Suomen Kulttuurirahasto
- Juho Vainion Säätiö
- Signe ja Ane Gyllenbergin Säätiö
- Emil Aaltosen Säätiö
- Sydäntutkimussäätiö
- Tampereen Tuberkuloosisäätiö
- Diabetesliitto
- Paavo Nurmen Säätiö
- Tays
- Syöpäsäätiö