Regulation of different types of diseases by lncRNA ADAMTS9-AS1
Long-stranded noncoding RNAs (lncRNAs) are a group of RNAs that are longer than 200 nucleotides and without protein-coding ability. Current researches indicated that the dysregulated expression of lncRNAs not only impaired normal cell growth and development, but also interfered with the cell cycle and cellular metabolism, thereby causing the development of various diseases. LncRNA ADAMTS9-AS1 is an antisense lncRNA produced by reversing transcription of ADAMTS9-AS1. LncRNA ADAMTS9-AS1 is closely related to different types of diseases. In addition to its own aberrant expression, it could also act as a miRNA sponge and competitively bind to miRNAs to participate in the process of disease occurrence through complex pathways and interactions with other genes and proteins. Therefore, this paper reviews the specific mechanism of lncRNA ADAMTS9-AS1 in different diseases, which promises to be a new biomarker and therapeutic target for a variety of diseases.
Authors
- Junyu He (ORCID: https://orcid.org/0000-0001-6969-8580)
- Haiming Tang (ORCID: https://orcid.org/0000-0001-7058-349X)
- Jihong Zhang (ORCID: https://orcid.org/0000-0001-8861-9956)
- Haoran Li (ORCID: https://orcid.org/0009-0005-2375-9188)
- Ying Zhang (ORCID: https://orcid.org/0000-0003-2639-504X)
- Jie Liu (ORCID: https://orcid.org/0000-0001-6035-0131)
- Jie Xu (ORCID: https://orcid.org/0000-0001-8712-7423)
- Chengfu Yuan (ORCID: https://orcid.org/0000-0002-0348-3146)
- Mengqiong Shi
Institutions
- China Three Gorges University (CN)
- Huazhong Agricultural University (CN)
Publication Details
- Journal
- Discover Medicine
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1007/s44337-025-00307-8
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Hubei Province