Sericin-Based 3D High-Precision Biomimetic Microscaffold Fabricated by Laser Direct Writing for Tissue Engineering
In tissue engineering, scaffolds are designed to mimic the extracellular matrix (ECM), creating three-dimensional (3D) microenvironments that support cell adhesion and growth. However, the precise fabrication of heterogenenous ECM-mimicking 3D microstructures remains an unsolved challenge. To address this, high-precise sericin-based scaffolds were developed via femtosecond laser direct writing (FsLDW) technology. Chemically modified sericin served as a monomer in the FsLDW process, achieving nanoscale precision and enabling the fabrication of arbitrary 3D sericin microstructures. Biomimetic 3D models, derived from natural tissue matrices, were employed to construct heterogenenous sericin bioscaffolds. These anisotropic scaffolds effectively supported cell directional growth and differentiation. This advancement greatly enhances the precision of sericin-based tissue-engineered scaffolds, enabling the creation of heterogenenous, multifunctional microenvironments that mimic natural ECM to support functional tissue development and address challenges in accurately simulating ECM microstructures in tissue regeneration.
Authors
- Wei Xiong (ORCID: https://orcid.org/0000-0002-2532-2503)
- Xuhao Fan (ORCID: https://orcid.org/0000-0002-6148-0883)
- Zexu Zhang (ORCID: https://orcid.org/0000-0003-1702-0385)
- Yu Song (ORCID: https://orcid.org/0000-0003-0192-9076)
- Chunsan Deng (ORCID: https://orcid.org/0000-0003-2301-474X)
- Mingduo Zhang (ORCID: https://orcid.org/0000-0003-0111-4088)
- Hui Gao (ORCID: https://orcid.org/0000-0002-2155-4681)
- Yuncheng Liu (ORCID: https://orcid.org/0000-0002-0456-7560)
- Chengfeng Yang (ORCID: https://orcid.org/0000-0002-2196-6854)
- Leimin Deng (ORCID: https://orcid.org/0000-0002-3361-8822)
- Huan Liu (ORCID: https://orcid.org/0000-0002-2042-368X)
- Zheng Wang (ORCID: https://orcid.org/0000-0002-9330-0728)
- Lin Wang (ORCID: https://orcid.org/0000-0001-5716-6587)
- Yan Deng (ORCID: https://orcid.org/0000-0002-9056-2554)
- Xinger Wang (ORCID: https://orcid.org/0009-0003-5667-8072)
Institutions
- Ministry of Education (CL)
- Wuhan National Laboratory for Optoelectronics (CN)
- Union Hospital (US)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Nano Letters
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1021/acs.nanolett.5c00346
- Citations
- 4
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- National Natural Science Foundation of China
- Science and Technology Department of Hubei Province
- National Key Research and Development Program of China