Detecting and characterizing copy number variation in a large commercial U.S. Holstein cattle population

We mapped and demonstrated the characteristics of genome-wide distributed CNVs in a large commercial Holstein population genotyped with a high-density SNP array. Collectively, the results emphasize the role of CNVs as a valuable resource of genetic variation and contribute to better understand the genetic architecture of economic complex traits in dairy cattle. Furthermore, these findings may provide opportunities for the development of novel and enhanced genomic selection strategies in Holstein cattle.