Single-Cell RNA Sequencing Revealed Functional Conjunctival Keratinocytes Loss via TGF-β-Wnt/β-Catenin Signaling in Sjögren’s Syndrome Related Dry Eye
In SS conjunctiva, a TGF-β-Wnt/β-catenin axis downregulated the formation of functional keratinocytes accompanied by infiltration of pro-angiogenetic and pro-fibrotic macrophage and pro-inflammatory T cell.
Authors
- Wenrui Deng
- Bowen Wang (ORCID: https://orcid.org/0000-0001-8466-4266)
- Xiaoran Wang (ORCID: https://orcid.org/0000-0003-4827-6930)
- Yang Xue (ORCID: https://orcid.org/0000-0002-7804-5730)
- Lihong Liang (ORCID: https://orcid.org/0000-0001-6906-0165)
- Runze Zhang (ORCID: https://orcid.org/0009-0004-9088-7924)
- Jin Yuan (ORCID: https://orcid.org/0000-0001-6807-1815)
- Hao Zeng (ORCID: https://orcid.org/0000-0002-2058-2787)
Institutions
- Beijing Tongren Hospital (CN)
- Sun Yat-sen University (CN)
- Capital Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1167/iovs.66.4.43
- Citations
- 2
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 3.76