TUT7-Mediated Uridine Degradation of MCPIP1 in the Pterygium to Regulate TRAF6-Mediated Autophagy
In summary, the current study revealed that MCPIP1 promotes autophagy by positively regulating the TRAF6-BECN1 signaling pathway, thereby suppressing pterygium development. Conversely, TUT7 uridylylation modulated MCPIP1's regulation of pterygium.
Authors
- Yanze Xu (ORCID: https://orcid.org/0000-0003-3314-9840)
- Yubing Zhao
- Yuru Yin (ORCID: https://orcid.org/0000-0002-7429-8941)
- Weijia Zhang (ORCID: https://orcid.org/0000-0002-6427-0056)
- Hao Ji (ORCID: https://orcid.org/0000-0003-1513-9884)
- Juanjuan Li (ORCID: https://orcid.org/0000-0003-4581-3788)
- Yan Du (ORCID: https://orcid.org/0000-0002-6991-2441)
- Dandan Zhao (ORCID: https://orcid.org/0009-0004-5500-0670)
- Anni He
Institutions
- Kunming University of Science and Technology (CN)
- Kunming Medical University (CN)
- First People's Hospital of Yunnan Province (CN)
- Yan'an Hospital Affiliated To Kunming Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1167/iovs.66.4.41
- Citations
- 2
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.71