Impaired cardiac branched-chain amino acid metabolism in a novel model of diabetic cardiomyopathy
A-PDK1KO mice closely mimic the cardiac phenotypes and metabolic alterations observed in human DbCM and exhibit impaired BCAA metabolism in the heart. This model may contribute to a better understanding of DbCM pathophysiology and to the development of novel therapies for this disease.
Authors
- Junko Asakura
- Tsutomu Sasaki (ORCID: https://orcid.org/0000-0001-8041-1915)
- Naoya Kuwahara
- Hiromasa Otake
- Tetsuya Hosooka (ORCID: https://orcid.org/0000-0002-9944-5418)
- Wataru Ogawa (ORCID: https://orcid.org/0000-0002-0432-4366)
- Masakazu Shinohara (ORCID: https://orcid.org/0000-0001-8724-0071)
- Sho Matsui (ORCID: https://orcid.org/0000-0003-1256-1182)
- Hidekazu Tanaka (ORCID: https://orcid.org/0000-0002-8673-5707)
- Manabu Nagao (ORCID: https://orcid.org/0000-0001-7269-4513)
- Seimi Satomi‐Kobayashi (ORCID: https://orcid.org/0000-0003-4656-260X)
- Tadahiro Kitamura (ORCID: https://orcid.org/0000-0001-8809-8740)
- Ryuji Toh (ORCID: https://orcid.org/0000-0002-7204-6695)
- Ken‐ichi Hirata (ORCID: https://orcid.org/0000-0002-6782-3031)
- Tatsuro Ishida (ORCID: https://orcid.org/0000-0002-1724-0057)
- Makoto Nishimori
Institutions
- University of Shizuoka (JP)
- Gunma University (JP)
- Kyoto University (JP)
- Kobe University (JP)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s12933-025-02725-5
- Citations
- 4
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- Uehara Memorial Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- Novo Nordisk
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Japan Diabetes Society
- SENSHIN Medical Research Foundation
- Japan Diabetes Foundation
- MSD Life Science Foundation, Public Interest Incorporated Foundation
- Novo Nordisk Pharma