Integrative metabolomics and genomics reveal molecular signatures for type 2 diabetes and its cardiovascular complications
WHAT IS CURRENTLY KNOWN ABOUT THIS TOPIC?: Metabolites are crucial for understanding diabetes biology.Multi-omics integration aids in revealing complex mechanisms. WHAT IS THE KEY RESEARCH QUESTION?: How do serum metabolites affect diabetes and its cardiovascular outcomes? WHAT IS NEW?: Novel diabetes-related metabolites identified in Chinese populations.Consistent metabolites associated with diabetes and glycemic traits in East Asians and Europeans.Emphasizing the role of urea cycle pathway in cardiometabolic disease. HOW MIGHT THIS STUDY INFLUENCE CLINICAL PRACTICE?: Findings could guide diabetes prevention and personalized management strategies.
Authors
- Lingyun Sun
- Yimin Zhu (ORCID: https://orcid.org/0000-0002-7569-2158)
- Zheng Lin (ORCID: https://orcid.org/0000-0001-5242-716X)
- Xiaohui Sun (ORCID: https://orcid.org/0000-0002-5743-8375)
- Yuanjiao Liu
- Ju‐Sheng Zheng (ORCID: https://orcid.org/0000-0001-6560-4890)
- Dan Zhou (ORCID: https://orcid.org/0000-0003-1765-6914)
- Chunxiao Cheng
- Jiayao Fan
Institutions
- Zhejiang Chinese Medical University (CN)
- Westlake University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
- Zhejiang University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s12933-025-02718-4
- Citations
- 9
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China