Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice
Corneal sensory nerve injury disrupts both central and peripheral circadian clock functions in the lacrimal gland, leading to reduced tear secretion and immune dysregulation. These findings highlight the novel role of circadian rhythms and neural-immune interactions in lacrimal gland dysfunction. Neural regeneration strategies, such as bFGF, offer therapeutic potential for dry eye syndrome, providing new directions for clinical intervention.
Authors
- Jingyi Xie (ORCID: https://orcid.org/0000-0002-8959-4268)
- Ruyu Yan
- Jiangman Liu
- Zhijie Li (ORCID: https://orcid.org/0000-0002-3186-144X)
- Jiaxin Wu
- Ting Fu (ORCID: https://orcid.org/0000-0002-1979-4184)
- Senmao Li (ORCID: https://orcid.org/0000-0002-4844-4503)
- Yunxia Xue
- Jiayan Xiang
- Liyuan Lu
- Qiwei Fan
- Jun Liu (ORCID: https://orcid.org/0009-0000-8133-558X)
Institutions
- Jinan University (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1167/iovs.66.4.40
- Citations
- 3
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 2.74