Polygenic Scores and Mood Disorder Onsets in the Context of Family History and Early Psychopathology
In this cohort study, multiple PGS were associated with mood disorder onset independent of family history of BD and premorbid diagnoses of ADHD or anxiety. The association between PGS and mood disorder risk varied depending on family history status.
Authors
- Emma K. Stapp (ORCID: https://orcid.org/0000-0003-0628-0704)
- Guy Armand Rouleau (ORCID: https://orcid.org/0000-0001-8403-1418)
- Benjamin I. Goldstein (ORCID: https://orcid.org/0000-0003-0340-349X)
- Danella Hafeman (ORCID: https://orcid.org/0000-0001-8312-3513)
- Melvin G. McInnis (ORCID: https://orcid.org/0000-0002-0375-6247)
- Martin Alda (ORCID: https://orcid.org/0000-0001-9544-3944)
- Peter R. Schofield (ORCID: https://orcid.org/0000-0003-2967-9662)
- Manon H. J. Hillegers (ORCID: https://orcid.org/0000-0003-4877-282X)
- Sergi Mas (ORCID: https://orcid.org/0000-0003-3336-6298)
- Janice M. Fullerton (ORCID: https://orcid.org/0000-0003-4014-4490)
- Rudolf Uher (ORCID: https://orcid.org/0000-0002-2998-0546)
- Claudio Toma (ORCID: https://orcid.org/0000-0003-3901-7507)
- Holly C. Wilcox (ORCID: https://orcid.org/0000-0003-2624-0654)
- Elena de la Serna (ORCID: https://orcid.org/0000-0002-7869-9881)
- Howard J. Edenberg (ORCID: https://orcid.org/0000-0003-0344-9690)
- John I. Nürnberger (ORCID: https://orcid.org/0000-0002-7674-1767)
- Lukáš Propper (ORCID: https://orcid.org/0000-0001-7857-1709)
- Gloria Roberts (ORCID: https://orcid.org/0000-0002-1966-5120)
- Neeltje E.M. van Haren (ORCID: https://orcid.org/0000-0002-3090-7653)
- Boris Birmaher
- Alyson Zwicker (ORCID: https://orcid.org/0000-0003-4500-3128)
- Samuel A. Stewart (ORCID: https://orcid.org/0000-0001-6299-7967)
- Dolores Moreno (ORCID: https://orcid.org/0000-0003-2994-7698)
- Gisela Sugranyes
- Kathryn Freeman (ORCID: https://orcid.org/0000-0002-7329-3348)
- Philip Bowden Mitchell (ORCID: https://orcid.org/0000-0002-7954-5235)
- John Merranko (ORCID: https://orcid.org/0000-0002-9162-5916)
- Josefina Castro-Fornieles
- Eileen M. Denovan‐Wright
- Barbara Pavlová
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Dalhousie University (CA)
- Milken Institute (US)
- Centre for Addiction and Mental Health (CA)
- Consejo Superior de Investigaciones Científicas (ES)
- Johns Hopkins University (US)
- University of Pittsburgh (US)
- University of Toronto (CA)
- George Washington University (US)
- University of Michigan (US)
- Western Pennsylvania Hospital (US)
- Saint John Regional Hospital (CA)
- Izaak Walton Killam Health Centre (CA)
- Erasmus MC (NL)
- Nova Scotia Health Authority (CA)
- Hospital General Universitario Gregorio Marañón (ES)
- University Medical Center Utrecht (NL)
- UNSW Sydney (AU)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Hospital Clínic de Barcelona (ES)
- Centro de Biología Molecular Severo Ochoa (ES)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Indiana University School of Medicine
- McGill University (CA)
- Indiana University – Purdue University Indianapolis (US)
- Universidad Autónoma de Madrid (ES)
- Universitat de Barcelona (ES)
- Neuroscience Research Australia (AU)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.5331
- Citations
- 4
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.88
Funders
- Dalhousie Medical Research Foundation
- Fundación Alicia Koplowitz
- Genome Canada
- Centres de Recerca de Catalunya
- European Commission
- Canada Research Chairs
- Generalitat de Catalunya
- Dalhousie University
- Genome Atlantic
- National Institutes of Health
- HORIZON EUROPE Framework Programme
- Canadian Institutes of Health Research
- National Health and Medical Research Council
- Instituto de Salud Carlos III
- European Regional Development Fund