Hepatotoxicity Among People With HIV and Receiving Isoniazid Preventive Therapy in Pregnancy and Postpartum: The Role of Antiretroviral Regimen and Pharmacogenetics
It is critical to monitor for hepatotoxicity in early postpartum, where there is higher risk compared to antepartum. ARV regimen and pharmacogenetics should also be considered in making decisions on when to initiate IPT in pregnant and postpartum populations.
Authors
- Tsungai Chipato (ORCID: https://orcid.org/0009-0001-3629-3429)
- Amita Jain Gupta (ORCID: https://orcid.org/0000-0001-7036-2718)
- Lisa Aaron
- Patrick Jean‐Philippe
- Lynda Stranix‐Chibanda (ORCID: https://orcid.org/0000-0003-3566-1688)
- Tichaona Vhembo (ORCID: https://orcid.org/0000-0002-2009-0432)
- Katie McCarthy
- Timothy R. Sterling (ORCID: https://orcid.org/0000-0002-4822-6979)
- Adriana Weinberg (ORCID: https://orcid.org/0000-0001-6920-0623)
- Gaerolwe Masheto (ORCID: https://orcid.org/0000-0002-2388-9637)
- Sarah Bradford (ORCID: https://orcid.org/0009-0000-5199-5093)
- Gerhard Barnard Theron (ORCID: https://orcid.org/0000-0001-8888-1436)
- Deo Wabwire (ORCID: https://orcid.org/0009-0001-8923-2005)
- Grace Montepiedra (ORCID: https://orcid.org/0000-0002-6866-4335)
Institutions
- Family Health International 360 (US)
- Johns Hopkins University (US)
- University of Zimbabwe (ZW)
- Stellenbosch University (ZA)
- Johns Hopkins Medicine (US)
- Cancer Research And Biostatistics (US)
- MUJHU Research Collaboration (UG)
- National Institute of Allergy and Infectious Diseases (US)
- Botswana Harvard AIDS Institute Partnership (BW)
- University of Colorado Anschutz Medical Campus (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1093/cid/ciaf198
- Citations
- 1
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.40