Risk-factors and multimorbidity in oral anticoagulant-related intracerebral haemorrhage: a comparison of patients in pivotal trials and real life
In conclusion, burden of risk-factors and comorbidities were similar in real-life patients with DOAC-ICH and VKA-ICH, as well as in real-life patients compared to trial-life patients. However, real-life patients especially those on DOAC, were older and more frequently women than trial-life patients. It is reassuring that burden of comorbidity was similar in real-life and trial-life patients. Nevertheless, this report underlines the importance of recruiting adequate numbers of older people and women to cardio-vascular trials to ensure sufficient safety data to advice prescriptions in these very prevalent sub-groups of patients.
Authors
- Karen Ægidius
- Jacob Marstrand
- Christina Kruuse (ORCID: https://orcid.org/0000-0002-4210-0523)
- Thomas Christensen (ORCID: https://orcid.org/0000-0003-4953-0814)
- Hanne Christensen (ORCID: https://orcid.org/0000-0002-7472-3194)
- David Gaist (ORCID: https://orcid.org/0000-0001-5205-7007)
- Inger Havsteen (ORCID: https://orcid.org/0000-0002-8110-8931)
- Alexander Lilja‐Cyron (ORCID: https://orcid.org/0000-0003-2915-249X)
- Helle Klingenberg Iversen (ORCID: https://orcid.org/0000-0002-5880-6352)
- Sverre Rosenbaum
- Thorsten Steiner (ORCID: https://orcid.org/0000-0002-5080-8222)
- Per Meden
- Christian Ovesen (ORCID: https://orcid.org/0000-0002-4870-4475)
- Josefine Grundtvig (ORCID: https://orcid.org/0000-0002-1006-1777)
- Louisa Christensen (ORCID: https://orcid.org/0000-0003-1448-5646)
Institutions
- Heidelberg University (DE)
- Odense University Hospital (DK)
- Bispebjerg Hospital (DK)
- University Hospital Heidelberg (DE)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Region of Southern Denmark (DK)
- Klinikum Frankfurt Höchst (DE)
Publication Details
- Journal
- Age and Ageing
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1093/ageing/afaf091
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lundbeckfonden