Biological sex influences severity and outcomes in <i>Acinetobacter baumannii</i> pneumonia
Biological sex has been shown to influence the incidence and outcomes of infection. We had previously documented that in a mouse model of infection, the pathogen <i>Acinetobacter baumannii</i> caused more serious pulmonary disease in female animals. In this study, we aimed to determine if this was evident in human pneumonia data. We found that, opposite to the mice data, human males had extended hospital stays due to <i>A. baumannii</i> pneumonia. We also identified a number of risk factors that can impact mortality and duration of hospital stay. This information could be used to guide efforts to improve management of patients with <i>A. baumannii</i> pneumonia.
Authors
- Dane Parker (ORCID: https://orcid.org/0000-0001-7304-3392)
- Arun Mattappallil (ORCID: https://orcid.org/0000-0002-5016-6565)
- Diana Finkel (ORCID: https://orcid.org/0000-0002-5947-9947)
- Matthew S. Linz (ORCID: https://orcid.org/0000-0002-5067-4893)
- Dov Levine (ORCID: https://orcid.org/0000-0003-1675-0116)
- D. Louis Collins (ORCID: https://orcid.org/0000-0002-8432-7021)
- Emily Keenan
- Ruchi Biswas (ORCID: https://orcid.org/0009-0004-2681-6494)
Institutions
- Rutgers, The State University of New Jersey (US)
- Johnson University (US)
- Rutgers Sexual and Reproductive Health and Rights (NL)
- Rutgers New Jersey Medical School (US)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1128/spectrum.03199-24
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Cystic Fibrosis Foundation
- Infectious Diseases Society of America