Lnc-DARVR/miR-365-1-5p/LAMB1 axis regulates rotavirus replication via the complement C3 pathway
Long non-coding RNAs (lncRNAs) play versatile and critical roles in host-virus interactions, offering significant potential for developing targeted therapies to prevent or treat viral infections. Despite their importance, the involvement of lncRNAs in rotavirus infection remains underexplored. This study identifies a novel lncRNA that enhances complement factor C3 activity through the competing endogenous RNA (ceRNA) mechanism, effectively inhibiting rotavirus replication across different subtypes. These findings underscore the complex molecular interplay regulating complement factor activity during rotavirus infection and provide valuable insights into the host's antiviral mechanisms. This research paves the way for innovative therapeutic strategies targeting lncRNAs and complement factors to combat viral infections more effectively.
Authors
- Xiaochen Lin (ORCID: https://orcid.org/0000-0002-0829-6761)
- Chenxing Lu
- Jinlan Wang (ORCID: https://orcid.org/0000-0002-4529-874X)
- Yan Zhou (ORCID: https://orcid.org/0000-0002-4706-1543)
- Xiaoqing Hu (ORCID: https://orcid.org/0000-0001-9824-1109)
- Xiaopeng Song (ORCID: https://orcid.org/0009-0000-6377-7026)
- Guangming Zhang (ORCID: https://orcid.org/0009-0005-7552-2561)
- Yan Li (ORCID: https://orcid.org/0000-0002-4658-2080)
- Jun Ye (ORCID: https://orcid.org/0000-0002-0536-6154)
- Rong Chen (ORCID: https://orcid.org/0000-0001-8751-9590)
- Hongjun Li (ORCID: https://orcid.org/0000-0001-6941-9852)
- Jinmei Li
- Xiangjun Kuang
- Lida Yao
- Jinyuan Wu (ORCID: https://orcid.org/0000-0001-6125-1821)
- Xianqiong Tang (ORCID: https://orcid.org/0000-0003-1731-9766)
- Qingmei Leng
- Maosheng Sun
Institutions
- Academy of Medical Sciences (GB)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Institute of Medical Biology (SG)
Publication Details
- Journal
- Journal of Virology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1128/jvi.02114-24
- Citations
- 3
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 4.19