Radiation induced dermatitis by increasing triglyceride levels to induce autophagy and inhibit the PI3K/Akt/mTOR signaling pathway
TGs are crucially involved in the development of RD. Increased TG levels after radiation treatment suppress the PI3K/Akt/mTOR pathway, induce autophagy, and exacerbate RD.
Authors
- Hongdan Guan
- Benhua Xu (ORCID: https://orcid.org/0000-0002-2184-577X)
- Yunhao Chen (ORCID: https://orcid.org/0000-0001-7471-3271)
- Ying Wang (ORCID: https://orcid.org/0000-0002-5662-909X)
- Yang Zhang (ORCID: https://orcid.org/0000-0002-2504-3117)
- Ying Hong (ORCID: https://orcid.org/0000-0003-0259-7878)
- Zheng‐Yi Zhou (ORCID: https://orcid.org/0000-0001-9014-8479)
- Rong Zheng (ORCID: https://orcid.org/0000-0002-0923-7106)
- Junjian Lin
- Xingchen Ding (ORCID: https://orcid.org/0000-0002-4229-5340)
- Yao Wang (ORCID: https://orcid.org/0000-0003-2480-3660)
Institutions
- Fujian Medical University (CN)
- Shandong Tumor Hospital (CN)
- Jiangsu Cancer Hospital (CN)
- Shandong First Medical University (CN)
- Union Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s12944-025-02553-2
- Citations
- 3
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 3.67
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Fujian Province