The transcription factor PITX1 cooperates with super-enhancers to regulate the expression of DUSP4 and inhibit pyroptosis in pulmonary artery smooth muscle cells
We confirmed that PITX1 can promote DUSP4 expression by binding to the DUSP4 promoter and SE to reduce pyroptosis in hypoxic PASMCs, providing new insights into the role of SEs and pyroptosis in pulmonary vascular remodeling and a theoretical basis for the treatment of PAH and related diseases.
Authors
- Xiaodong Zheng (ORCID: https://orcid.org/0000-0002-6103-9836)
- Songyue Li (ORCID: https://orcid.org/0000-0001-7161-3881)
- Yuyu Song (ORCID: https://orcid.org/0000-0002-9196-1610)
- Jingya Zhang
- Xu Wang (ORCID: https://orcid.org/0000-0001-6920-0375)
- Xinyue Song (ORCID: https://orcid.org/0000-0001-8238-309X)
- Chong Zhao (ORCID: https://orcid.org/0000-0003-3271-5783)
- Xinru Wang (ORCID: https://orcid.org/0000-0002-8340-243X)
- Yan Xing (ORCID: https://orcid.org/0000-0003-2150-1448)
- Jing Qi (ORCID: https://orcid.org/0000-0002-5688-5579)
- Yunyun Tian
- Baoshan Zhao
Institutions
- Harbin Medical University (CN)
- Daqing City People's Hospital (CN)
- Gaozhou People's Hospital (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s12931-025-03222-9
- Citations
- 4
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Harbin Medical University
- National Natural Science Foundation of China