Renal Status in Newly Diagnosed Patients with Diabetes Mellitus: A Descriptive Study in Primary Care and Opportunities for Improving Management

<b>Background/Objectives:</b> The current study aims to estimate the frequency of abnormal renal status (ARS, defined as chronic kidney disease (CKD) diagnosis in electronic medical records or current albuminuria) in people with newly diagnosed diabetes mellitus (DM), to determine the associated risk factors, and to evaluate the level of compliance with good clinical practice recommendations. <b>Methods:</b> Cross-sectional study with 1030 adults diagnosed with DM in the last 4 years. Anthropometric, clinical, analytical, and lifestyle variables were collected. Multivariate analyses were performed to determine the factors associated with ARS. <b>Results:</b> Hypercholesterolaemia, metabolic syndrome, hypertension, obesity, hypertriglyceridaemia, and cardiovascular disease (CVD) were the most prevalent comorbidities. ARS was present in 11.5% of patients. The variables associated with ARS were male sex (OR: 1.78; 95% CI, 1.16-2.75), age ≥70 years (OR: 2.96; 95% CI: 1.92-4.56), hypertension (OR: 1.59; 95% CI: 1.03-2.44), CVD (OR: 1.73; 95% CI: 1.03-2.90), and hemoglobin A1c (HbA1c) ≥8% (OR: 2.26; 95% CI, 1.19-4.27). Among patients with hypertension and albuminuria, 80% received angiotensin-converting enzyme inhibitors (ACE inhibitor) or an angiotensin receptor blocker (ARB), compared to 60% of those with albuminuria without hypertension. The 42.4% patients with ARS were treated with sodium-glucose cotransporter type 2 inhibitors (SGLT2i) and 72% with statins, but only 31.5% achieved the target low density lipoproteins cholesterol (LDLc) < 70 mg/dL. <b>Conclusions:</b> ARS in newly diagnosed patients with DM is less common than described in the literature, but risk factors for its development are highly prevalent. Adherence to good clinical practice recommendations was poor, especially in LDL cholesterol targets and the use of SGLT2i.

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Publication Details

Journal
Journal of Clinical Medicine
Published
2025-04-16
DOI
https://doi.org/10.3390/jcm14082732
Citations
1
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
1.29

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article

Renal Status in Newly Diagnosed Patients with Diabetes Mellitus: A Descriptive Study in Primary Care and Opportunities for Improving Management

Rainer Rothe Muñoz, Miguel Ángel Salinero-Fort, Pilar Vich-Pérez, Belén Taulero-Escalera et al.
1 citations
Journal of Clinical Medicine
Diabetes Treatment and Management
1.29
article

Renal Status in Newly Diagnosed Patients with Diabetes Mellitus: A Descriptive Study in Primary Care and Opportunities for Improving Management

Rainer Rothe Muñoz, Miguel Ángel Salinero-Fort, Pilar Vich-Pérez, Belén Taulero-Escalera, Paula Regueiro-Toribio, A Miguel
article en
1 citations

Abstract

<b>Background/Objectives:</b> The current study aims to estimate the frequency of abnormal renal status (ARS, defined as chronic kidney disease (CKD) diagnosis in electronic medical records or current albuminuria) in people with newly diagnosed diabetes mellitus (DM), to determine the associated risk factors, and to evaluate the level of compliance with good clinical practice recommendations. <b>Methods:</b> Cross-sectional study with 1030 adults diagnosed with DM in the last 4 years. Anthropometric, clinical, analytical, and lifestyle variables were collected. Multivariate analyses were performed to determine the factors associated with ARS. <b>Results:</b> Hypercholesterolaemia, metabolic syndrome, hypertension, obesity, hypertriglyceridaemia, and cardiovascular disease (CVD) were the most prevalent comorbidities. ARS was present in 11.5% of patients. The variables associated with ARS were male sex (OR: 1.78; 95% CI, 1.16-2.75), age ≥70 years (OR: 2.96; 95% CI: 1.92-4.56), hypertension (OR: 1.59; 95% CI: 1.03-2.44), CVD (OR: 1.73; 95% CI: 1.03-2.90), and hemoglobin A1c (HbA1c) ≥8% (OR: 2.26; 95% CI, 1.19-4.27). Among patients with hypertension and albuminuria, 80% received angiotensin-converting enzyme inhibitors (ACE inhibitor) or an angiotensin receptor blocker (ARB), compared to 60% of those with albuminuria without hypertension. The 42.4% patients with ARS were treated with sodium-glucose cotransporter type 2 inhibitors (SGLT2i) and 72% with statins, but only 31.5% achieved the target low density lipoproteins cholesterol (LDLc) < 70 mg/dL. <b>Conclusions:</b> ARS in newly diagnosed patients with DM is less common than described in the literature, but risk factors for its development are highly prevalent. Adherence to good clinical practice recommendations was poor, especially in LDL cholesterol targets and the use of SGLT2i.

Journal of Clinical MedicineVol. 14(8)
Hospital La Paz Institute for Health Research (ES), Madrid Health Service (ES)
Instituto de Salud Carlos III
Good health and well-being
Openalex Percentile: Top 21%
Diabetes Treatment and Management
1.29
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