Continuous 1,4/1,6- and 1,2-addition reactions combined with the skeletal rearrangement of 5a <i>H</i> ,13 <i>H</i> -chromeno[2,3- <i>b</i> ]quinolizin-13-ones with isocyanides to enable the synthesis of pyrido[2,3- <i>b</i> ]indolizines
We developed a protocol for synthesis of PDIZs from CMQZs with isocyanides. The cycloaddition of [1,4]/[1,6]/[1,2] and skeletal rearrangement were performed by heating a mixture of 1–2 in DMSO, which was promoted by Cs 2 CO 3 and catalyzed by Ag 2 CO 3 .
Authors
- Jia-Ming Yang
- Sheng‐Jiao Yan (ORCID: https://orcid.org/0000-0002-7430-4096)
- Bi−Na Shao
- Weimin Zhang (ORCID: https://orcid.org/0000-0001-8945-9448)
- Li Chen (ORCID: https://orcid.org/0000-0002-9650-497X)
Institutions
- Yunnan University (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5qo00342c
- Citations
- 1
- Primary Topic
- Synthesis and Reactivity of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.94