Photoredox/Palladium-Catalyzed Reduction Alkylation of Imines and Ammonium Salts via Dual C–N Bond Cleavage
Here, we report a photoredox/palladium-catalyzed reduction alkylation of imines and ammonium salts via dual C-N cleavage. This reaction proceeds under mild, green, and operationally simple conditions, offering a broad scope of secondary amine compounds with alpha quaternary carbon. Mechanistic studies indicate that the α-amino carbanion, generated by a successive single-electron transfer process, is a key intermediate in photoredox/palladium catalysis.
Authors
- Tao Ju (ORCID: https://orcid.org/0000-0003-0532-332X)
- Jian Xiong (ORCID: https://orcid.org/0000-0002-8346-178X)
- Chao‐Guo Yan (ORCID: https://orcid.org/0000-0002-2777-9582)
- Ying Han (ORCID: https://orcid.org/0000-0002-2424-5163)
- Kun Huang (ORCID: https://orcid.org/0000-0002-6933-6480)
- Jing Sun (ORCID: https://orcid.org/0000-0003-1267-0215)
- Zhi‐Hao Wang (ORCID: https://orcid.org/0000-0001-9722-0429)
- Ai-Ling Lu
Institutions
- Kanion Pharmaceutical (China) (CN)
- Taiwan Centers for Disease Control (TW)
- Yangzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1021/acs.joc.5c00098
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Jiangsu Province
- Natural Science Research of Jiangsu Higher Education Institutions of China