Selenium‐Albumin Nanoaccelerator Hydrogel Promotes Wound Healing by Antibacterial, Anti‐Inflammatory and Antioxidant along with Inhibits Scar Formation via Downregulating CD36

Wounds repairing after skin damage or diabetes remain a vast medical challenge, which often faces infection, inflammation, oxidative stress, and skin scarring. Herein, a multifunctional selenium-albumin nanoaccelerator hydrogel (H-Se NPs-Gel) is constructed based on the self-assembly of human serum albumin (HSA) with selenium nanoparticles (Se NPs) using carbomer as the carrier, it has remarkable antibacterial, anti-inflammatory, antioxidant and inhibits scarring properties than Se NPs for wound healing. Compared with Se NPs, H-Se NPs exhibit smaller particle sizes, exceptional stability, better antibacterial activity against common bacteria and MRSA, and superior antioxidant and anti-inflammatory capabilities in vitro without remarkable toxicity on skin cells. Importantly, it exhibits superior efficacy to Se NPs-Gel in accelerating the healing of full-thickness skin defects and diabetic wounds in mice. Interestingly, in a hypertrophic scar (HTS) model, H-Se NPs-Gel is more effective than Se NPs-Gel in inhibiting collagen formation to suppress scarring, which is mediated by the inhibition of CD36. The antagonistic effect of H-Se NPs on CD36 is also proved with the CD36 overexpression model. Furthermore, H-Se NPs-Gel demonstrates excellent safety in mice without systemic toxicity. H-Se NPs-Gel is an effective and safe therapy strategy for promoting wound healing and reducing scar formation in clinic.