Role of hsa_Circ_0001821 in Colorectal Cancer Pathogenesis and Response to 5-Fluorouracil through miR-203a-3p/FGF-2 Axis
Our study reveals the potential role of hsa_Circ_0001821 in controlling the tumor cell viability and response to 5-FU by targeting the hsa-miR-203a-3p/FGF-2 axis. These findings enhance our understanding of the molecular mechanisms that influence chemotherapy response in CRC, paving the way for the identification of more effective treatments for this disease.
Authors
- Pejman Molaei (ORCID: https://orcid.org/0000-0002-7348-9041)
- Mehrdad Hashemi (ORCID: https://orcid.org/0000-0003-0627-6991)
- Saeid Afshar (ORCID: https://orcid.org/0000-0001-5136-4259)
- Rezvan Najafi (ORCID: https://orcid.org/0000-0003-1326-1288)
- Ali Mahdavinezhad (ORCID: https://orcid.org/0000-0002-1314-8229)
- Leili Tapak
Institutions
- Hamedan University of Medical Sciences (IR)
- Islamic Azad University Medical Branch of Tehran (IR)
Publication Details
- Journal
- Iranian Biomedical Journal
- Published
- 2025-01-01
- DOI
- https://doi.org/10.61882/ibj.4942
- Citations
- 1
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Hamadan University of Medical Sciences