Melittin inhibits proliferation, migration, and invasion in osteosarcoma cell lines using 2D and 3D models
We conclude that melittin has antitumor and antimetastatic properties in canine, murine and human osteosarcoma cell lines. Consequently, we believe that further research on this promising compound will facilitate its application in the development of therapeutic agents for osteosarcoma, ultimately contributing to improved survival outcomes for cancer patients.
Authors
- Rui Seabra Ferreira (ORCID: https://orcid.org/0000-0001-6952-0512)
- Giovana Pedro (ORCID: https://orcid.org/0000-0001-8882-5223)
- Felipe César da Silva Brasileiro (ORCID: https://orcid.org/0000-0003-3394-991X)
- Aline Márcia Marques Braz (ORCID: https://orcid.org/0000-0002-5283-2373)
- Renée Laufer Amorim (ORCID: https://orcid.org/0000-0002-8653-7938)
Institutions
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- The Journal of venomous animals and toxins including tropical diseases
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1590/1678-9199-jvatitd-2024-0053
- Citations
- 2
- Primary Topic
- Healthcare and Venom Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79