Research Progress on the Etiology of Cholestatic Liver Disease in School-Age Children

胆汁淤积性肝病(Cholestatic Liver Disease, CLD)在中国儿童群体中是导致肝病住院的主要原因之一，其复杂的病因学特征使得准确区分不同病因颇具挑战。鉴于不同病因引发的CLD具有迥异的临床进程和预后效果，早期识别病因对于制定临床诊断策略和预测疾病进展至关重要。本文针对学龄期儿童胆汁淤积性肝病的致病因素进行了全面梳理，同时引入现阶段相关研究的新动向，以期为临床实践提供科学依据，从而制定出更具针对性的干预策略，进而优化患儿的预后管理。Cholestatic liver disease (CLD) is one of the main causes of liver disease hospitalization in Chinese children. Its complex etiological characteristics make it challenging to accurately distinguish different causes. Given that CLD caused by different etiologies has distinct clinical courses and prognoses, early identification of the cause is crucial for formulating clinical diagnostic strategies and predicting disease progression. This article comprehensively reviews the pathogenic factors of CLD in school-aged children and introduces the latest research trends in this field to provide a scientific basis for clinical practice, thereby formulating more targeted intervention strategies and optimizing the prognosis management of affected children.