Plasma Proteomics of the Fontan Circulation Reveal Signatures of Oxidative Stress and Cell Death
Proteins from circulating microvesicles from patients with hypoplastic left heart syndrome post-Fontan are mostly from the liver. While this pilot study is limited by its sample size and may not represent the broader Fontan population, the proteomic changes were associated with worsening heart failure and cyanosis, suggesting their potential utility as biomarkers.
Authors
- Laura Mercer‐Rosa (ORCID: https://orcid.org/0000-0003-2170-5942)
- Sushma Reddy (ORCID: https://orcid.org/0000-0003-3530-8630)
- Ankit Kushwaha (ORCID: https://orcid.org/0009-0006-9458-5813)
- Katie L. Clouthier (ORCID: https://orcid.org/0000-0002-1877-2557)
- Joiliana Lecointe (ORCID: https://orcid.org/0000-0001-9896-3590)
- S Ichimura
- Sushrima Gan (ORCID: https://orcid.org/0000-0002-0221-9925)
- Dipti Tripathi (ORCID: https://orcid.org/0000-0001-7296-6654)
Institutions
- Meharry Medical College (US)
- Children's Hospital of Philadelphia (US)
- Children's Hospital of Los Angeles (US)
- Palo Alto University (US)
- Cardiovascular Institute of the South (US)
- Stanford University (US)
Publication Details
- Journal
- Circulation Heart Failure
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1161/circheartfailure.124.012136
- Citations
- 5
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.03