T <sub>reg</sub> Cells Attenuate Pulmonary Venous Remodeling in PH-LHD via NLRC3 Signaling
NLRC3 is crucial for T<sub>reg</sub> cells to prevent pulmonary venous remodeling in PH-LHD, primarily by modulating IL-18 secretion, which inhibits endothelial-to-mesenchymal transition and thereby improves disease progression and prognosis.
Authors
- Yefei Shi (ORCID: https://orcid.org/0000-0001-6390-3539)
- Yanxi Zeng
- Peinan Ju (ORCID: https://orcid.org/0009-0002-1761-2065)
- Wenhui Peng (ORCID: https://orcid.org/0000-0003-2937-0024)
- Nuerbiyemu Maimaitiaili
- Yunshan Cao (ORCID: https://orcid.org/0000-0001-8463-1093)
- E Guangxi
- Hongyun Yao (ORCID: https://orcid.org/0009-0008-0883-7418)
- Gulinigeer Zhakeer
- Ke Li (ORCID: https://orcid.org/0009-0004-0759-8102)
- Qing Yu (ORCID: https://orcid.org/0000-0001-7051-3408)
- Ming Zhai (ORCID: https://orcid.org/0000-0002-6824-3063)
- Jianhui Zhuang
Institutions
- Tongji University (CN)
- University of Electronic Science and Technology of China (CN)
- XinHua Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- Tibet Autonomous Region People's Hospital (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1161/circresaha.124.325201
- Citations
- 6
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 4.78